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Recherche sur le gène CURLY

Etude de l'INRA (Institut National de la Recherche Agronomique) sur le gène Curly et sur les relations avec les qualités hypoallergéniques du cheval Curly

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Horse Allergy: Curly Horses Allow Horse Allergic Riders To Ride Again,An Observational Study

Pferdeallergie: Curly Horses erlauben es pferdeallergischen Reitern wieder zu reiten
Eine Beobachtungsstudie, W. Mitlehner, H. C. Mitlehner, B. Niggemann

Pneumologie 2015; 69(12): 711-718
DOI: 10.1055/s-0034-1393396, Original Paper

© Georg Thieme Verlag KG Stuttgart  New York

This study has been published in englisch (e pub first). The study demonstrates the results of 3 year research in 40 horse allergic riders who uses the curly horses. In this study we report the results of lung function measurements and nasal function during and after riding and after brushing curly horses. In this study the allergenic property of different phenotypes of curly horses in relation to normal horses has been tested by skin prick tests and the long term contact result to curly horses has been investigated. Until now we included 60 pts. in this research program.

Since 2014 we perform a second study for investigating the effect of curly horses on horse allergy.


Horse Allergy: Curly Horses Allow Horse Allergic Riders To Ride Again.
Mitlehner W1, Mitlehner HC2, Niggemann B3.
Author information  Abstract
To test the hypothesis that so called hypoallergenic horses (Curly horses) allow horse allergic riders to ride again, we investigated 40 horse allergic riders in a period of 37 months. Methods: We tested these patients (pts.) by skin prick test (SPT) with different non-curly and Curly horses and studied the riding hours and horse brushing by measurements of peak expiratory flow (PEF) and Tiffeneau tests (FEV1) as well as peak nasal inspiratory flow (PNIF) over 12 months. The results in 37/40 pts. showed no relevant reactions of the lower airways or nasal flow. Only in 3/40 patients an initial significant fall of FEV1 was observed, reversed by a single inhalation of salbutamol and not repeated despite further riding contact. In contrast to other allergic events (e. g. baker's asthma) a further and regular contact with these horses abolished the mild allergic reactions of the start period of contact. This may be due to hypoallergenic properties of these horses, whose test material produces weaker reactions in the SPT than that of normal horses. After a period of three years, a loss of reactivity to normal horses could be confirmed in some of the riders. Conclusion: The tested purebreed Curly horses may be a suitable alternative for horse allergic riders if the methodological precautions of this study are followed.
© Georg Thieme Verlag KG Stuttgart · New York.
Pneumologie. 2015 Dec;69(12):711-718. Epub 2015 Dec 9

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